Be sure to read this information carefully each time. (To learn more, see the Precautions for Prolia section below.). If you develop high cholesterol with Prolia, your doctor can guide you on which treatment options are right for your condition. Doing so will help you avoid the risk for a low calcium level during treatment. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Having dental procedures, including tooth extractions, during Prolia treatment may increase your risk of dental side effects. Prescribing Information and Also, hair loss may be related to other medications you take or health conditions you have. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.). Because these reports happened after the studies, it isnt known for sure whether Prolia caused hair loss, or if it was due to another reason. They include: not getting enough calcium and vitamin D smoking drinking too much alcohol using certain medications, such as corticosteroids and anticonvulsants not getting enough weight-bearing exercise (at least 30 minutes on most days). Tell them if you have any scheduled dental work coming up. See additional information. Prolia can also increase this risk. These side effects may be temporary, lasting a few days or weeks. To learn more about these two drugs, check out this drug article. It strengthens your bones by stopping certain bone cells called osteoclasts from breaking down your bones. Fracture in the spine after stopping Prolia treatment. WebNow that Im taking Prolia, do I still need calcium and vitamin D? Prolia may be used off-label for RA, if you have a high risk for bone fractures. For instance: Both Prolia and Forteo are given as injections under your skin. Serious side effects of Prolia that have been reported include: For most people, Prolias side effects are mild and go away after a few days to a few weeks. But hair loss has been reported by people who have taken Prolia since then. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. Prolia (denosumab) and Reclast (zoledronic acid) are injections that can be used to treat or prevent osteoporosis in postmenopausal women. * For more information about this side effect, see Side effect specifics below. Based on your dental history, your doctor can discuss with you the risks of using Prolia. Its recommended that calcium and vitamin D supplements be taken For more information, you can refer to the drugs prescribing information. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Prolia can also cause bones to not form correctly and reduced growth in a fetus. Yoga is an excellent way to manage symptoms of osteoporosis. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Prolia improves bone mass and increases bone mineral density. As you age, your BMD is reduced, and this may increase your risk for osteoporosis. See what this means for you in the chart below. Bring someone with you to your appointment if doing so will help you feel more comfortable. Prolia is an injection prescribed for certain adults with osteoporosis, which Our website services, content, and products are for informational purposes only. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using Prolia. Some items may interact with your medicine. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. And in my mind, that's no different than scheduling a visit to the dentist twice a year. (Vitamin D helps your body absorb calcium.) Theres no information available to know whether Prolia is passed into breast milk or if its safe to take while breastfeeding. If youre concerned about hair loss with Prolia, talk with your doctor. Prolia may lower the calcium levels in your blood. Before your appointment, write down questions, such as: How will Prolia affect my body, mood, or lifestyle? Protect from light and do not freeze. This can cause your weight to change and may explain any weight gain since starting Prolia treatment. Call your doctor right away if you have an allergic reaction to Prolia. Serious skin infections may occur, but are uncommon Prolia Prolia is injected under the skin. Theyll need to confirm that you arent pregnant. They can treat the infection as needed. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. Common side effects of this osteoporosis treatment injection include muscle, joint, and back pain. BMD was increased by 8.8% at the lumbar spine, 6.4% at the total hip, and 5.2% at the femoral neck in trials that measured BMD after three years of treatment with Prolia. What are some frequently asked questions about Prolia? We avoid using tertiary references. Different individuals may respond to medication in different ways. Continue reading, Prolia (denosumab) has not been associated with weight gain in clinical studies. And some of these side effects are more common with certain uses of Prolia. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. You may also want to do some research on your own. Prolia may cause serious side effects. This is not a complete list of warnings for Prolia. Take good care of your teeth and gums while you receive Prolia. For Xgeva, talk to your pediatrician regarding the use of this medicine in children. For this reason, some calcium supplements are combined with vitamin D. This vitamin is available in two forms, vitamin D 2 (ergocalciferol) and vitamin Examples of conditions Prolia is used off-label to treat include: Prolia is one option available to treat osteoporosis and reduce bone loss in people with a high risk for bone fracture. In rare cases, your doctor may have you self-inject Prolia at home. This may help to protect healthy cells from damage. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. Prolia may cause serious side effects. Follow your doctor's instructions. Drug class: Miscellaneous bone resorption inhibitors. in your skin, lower stomach area (abdomen), bladder, or ear may happen. But weight gain may be a symptom of a side effect called peripheral edema. Whats the Connection Between Estrogen and Osteoporosis? Youll get Prolia injections from a healthcare professional once every 6 months. Another common osteoporosis medication is denosumab (Prolia, Xgeva). Its possible that some of Prolias side effects may be long term, but theyre rare. More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Osteoporosis Medications (Bisphosphonates) - Johns Hopkins Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. Call your doctor for medical advice about side effects. Prolia And theyll recommend if its the best option for your condition. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. Breastfeeding. Last updated on Feb 8, 2023. Lifestyle changes that can help improve cholesterol levels include exercising regularly and eating a healthy diet. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. Youll receive 60 mg/mL of Prolia once every 6 months. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of calcium and at least 400 IU of vitamin D daily. Terms of Use. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. What should I know about Prolia vs. Evenity? Continue reading, Yes, Prolia does appear to weaken your immune system. How long will the side effects of Prolia last? But theyre each effective in treating osteoporosis and preventing bone loss. Find out which foods can help. Prolia is meant to be used in combination with calcium and vitamin D supplements. Here are a few questions to consider asking your doctor: You can also learn more about osteoporosis treatment options here. It could harm the unborn baby or cause birth defects. With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. Calcium and calcium supplements: Achieving the right Forteo is given as a self-injection once daily. You Prolia works by blocking osteoclasts (certain bone cells) from breaking down bone tissue in your body. You may need to have a dental exam before you begin treatment with Prolia. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. The ADA also provides recommendations to help your dentist in reducing your risk for these side effects while youre taking Prolia. Talk with your doctor if youd like to know about taking generic denosumab. Visit your doctor or health care professional for regular checks on your progress. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. If your pain doesnt ease with OTC options, your doctor may suggest prescription pain medication. This information is intended only for U.S. healthcare professionals. Motion sickness, nausea, and vomiting can occur as a part of vertigo. You should talk with your doctor if you develop any mild side effects that concern you. Prolia works by targeting a molecule called RANKL that osteoclasts need to work. You can use the study as a second opinion to make health care decisions. Serious side effects that have been reported and their symptoms include: * To learn more, see Does Prolia cause long-term side effects? in the FAQs about the side effects of Prolia section below. They might also recommend physical therapy, massage therapy, or using a heating pad. The Prolia is making my leg bones and jaw bones hurt. It is often used in osteoporosis. To date, the consensus is that there has been no proven risk of increased cardiovascular risk with intake of calcium supplements. Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. Both medications are approved to treat certain people with osteoporosis, as well as people with other conditions. Yes, if recommended by your doctor, you can stop taking Prolia. DENOSUMAB (den oh sue mab) slows bone breakdown. 8,432 people who take Prolia and Calcium together, and have interactions are studied. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. As mentioned above, Prolia contains the active drug denosumab. Stopping some drugs leads to withdrawal symptoms because your body is used to the drug and needs it for you to feel normal. Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. The risk is real, but rare. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. With arthritis, you have pain and inflammation of your joints. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. Osteoporosis Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. What are the possible side effects of Prolia? 2023 Healthline Media LLC. While youre receiving Prolia treatment, your doctor will monitor your cholesterol levels with regular blood tests. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. if you are taking medicine that lower your blood calcium levels. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. All subjects in the clinical trials of Prolia received 800mg of calcium and Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. But Prolia is given once every 6 months by a healthcare professional. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. So your healthcare provider will likely ask you to take calcium and vitamin D supplements if youre not taking them already. If youre breastfeeding, you should not receive Prolia. These side effects may include: Its not known what percentage of people in clinical trials developed dental or jaw-related side effects. This aids in keeping your calcium level within the recommended range. Some people may have an allergic reaction to Prolia. Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. But its not clear whether this side effect occurred in clinical studies. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). It is given by a health care professional in a hospital or clinic setting. Learn strategies you can use today. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.ada.org/en/member-center/oral-health-topics/osteoporosis-medications, https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125320s210lbl.pdf, New clues to slow aging? Keep in mind that Prolia is used to help strengthen your bones and prevent fractures, which may happen with falls. Talk to your health care professional or pharmacist for more information. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. Its important to tell your doctor if you have serious or ongoing side effects. A special MedGuide will be given to you before each treatment. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. If your Prolia treatment is stopped, talk to your doctor about other medicine that Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. Some examples of these treatments include: Talk with your doctor about other drugs you may need to take with Prolia. Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. (Biologic medications are made from living organisms.). This helps treat osteoporosis by improving bone mass and strengthening your bones. But if youre planning to have surgery, you may need to take a break Thyroid or parathyroid surgery. They may also have you see your dentist. This is because the drug may be harmful to a growing fetus. Prolia can cause certain side effects, some of which are more common than others. If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. If you want to stop taking Prolia, tell your doctor. Version: 13.01. hydrochlorothiazide, alendronate, Fosamax, calcium carbonate, Premarin, Tymlos. This includes proper brushing, flossing, mouthwash use, and regular professional dental cleanings. This was one of the most common side effects in clinical trials of females who received Prolia for osteoporosis after menopause. Pay special attention to your dental hygiene. Ask your doctor about your own risk. These effects are called interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. You may need to go to the hospital for treatment. You should also talk with them if you have any serious side effects during Prolia treatment. You might like to know how Prolia and the drug Evenity compare. kidney disease (or if you are on dialysis); a weak immune system (caused by disease or by using certain medicines); hypoparathyroidism (decreased functioning of the parathyroid glands); any condition that makes it hard for your body to absorb nutrients from food (malabsorption); if you are scheduled for a dental procedure; if you cannot take daily calcium and vitamin D; or. They have some similar uses and side effects, but they also have some differences. you can take. But Zometa contains the active drug zoledronic acid. Personalize this study to your gender and age, Arthrotec and Alanine Aminotransferase Increased, Capecitabine and Lumigan drug interaction, Cyramza and Gastrointestinal Stoma Necrosis, Simponi Aria and Pennsaid drug interaction, Docetaxel and Infection In An Immunocompromised Host, Ketorolac Tromethamine and Bladder Obstruction, Roxicodone and Caspofungin Acetate drug interaction, Ginkgo and Nitrofurantoin drug interaction. And some of these side effects are more common with certain uses of Prolia. Now i'm wondering if i shouldn't take K2. Please see Prolia full Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture Use of the terms female and male in this article refers to sex assigned at birth. Also, its important to brush and floss your teeth regularly while youre using Prolia. Take only the amount of calcium and vitamin D that your doctor has prescribed. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. Heres a short list of some of the mild side effects that Prolia can cause. In addition, you should use effective birth control while youre taking Prolia. Do not use denosumab if you are pregnant. But this isnt the case with Prolia. There are no known interactions with Prolia and other medications, supplements, or other products. This increases your risk for bone fractures. They can also tell you about other treatment options available for osteoporosis and bone loss prevention. Healthline Media does not provide medical advice, diagnosis, or treatment. Learn how to slow it down and fortify your body against it. Serious side effects from Prolia can occur, but they arent common. You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. There arent any studies that have compared these two drugs to each other. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.). Youll likely receive Prolia long term if you and your doctor decide that the drug is effective and safe for you. Keep in mind that side effects of a drug can depend on: Additionally, you may experience different side effects from those listed below based on the condition youre treating with Prolia. Prolia comes with a warning about a low level of calcium in the blood. You may need to stop using the medicine for a short time. Prolia Side Effects: Common, Mild, and Serious - Healthline Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Do not stop using this medicine without first talking to your doctor. Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. Sciatica is described as a shooting pain that travels from the lower back down a leg. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Prolia may not be right for you if you have certain medical conditions or other factors that affect your health. You may want to know how Prolia compares to the medication Tymlos. Prolia (denosumab) injection, for subcutaneous use. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. But doing so can cause more bone breakdown and increase your risk for bone fractures. Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication.
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